Abstract: Endogenous endophthalmitis is a severe, sight-threatening infectious ocular condition. In East Asia, hypervirulent Klebsiella pneumoniae represents the predominant pathogen, and infected individuals often present with concurrent invasive infections in systemic sites such as the liver, lungs, and urinary tract. The disease predominantly affects patients with underlying conditions such as diabetes, immunosuppression, or renal impairment, and may occur across all age groups. Diagnosis is primarily based on clinical presentation and ophthalmological examination, rather than relying exclusively on microbiological culture results. Current management mainly consists of systemic antimicrobial therapy combined with local treatments. In recent years, several novel antibacterial strategies have emerged, demonstrating considerable potential for future clinical application.

Key words: Endogenous endophthalmitis, Highly virulent Klebsiella pneumoniae